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Frequently Asked Questions about Isotonix™ Calcium Plus (FAQs):
Why is boron omitted from the Calcium Plus formula?
Boron is thought to aid the uptake of calcium and magnesium into osteoblasts in the bone, thus increasing the density of bone. The Therapeutic Goods Administration does not believe there is sufficient evidence of a nutrient effect from boron.
Why does the Calcium bottle state for it to be taken twice a day, whereas the other Isotonix™ products only recommended one serve per day?
The body tightly regulates the amount of calcium that it absorbs. The body can only absorb 400-500 milligrams of calcium at one time, and as the calcium dose increases, the efficiency of absorption declines rapidly. The label for Isotonix Calcium Plus recommends taking the product in a split dosage — one capful in the morning (272 mg), one capful in the evening (272 mg) — to accommodate the body's physiological behaviour.
When we claim our products are Isotonic, is there any formal experiment or report to prove the absorption rate and the isotonic state?
Isotonix products make the label claim of being isotonic capable. When prepared as directed, the solution is within a range of tonicity matching the human body.
The basis for the isotonic line is physiologic. Isotonic solutions work via normal body physiology to deliver nutrients quickly as compared to solid forms. These physiologic principles have been well described in medical references and in the medical literature. Here are a few sample references:
o Ganong, WF Review of Medical Physiology, 13th ed. Norwalk, CT Appleton & Lange, 1987.
o Graham, DY, Smith, JL, Bouvet AA "What Happens to Tablets in the
Stomach" Journal of Pharmaceutical Sciences 79 (5): 420-24, 1990.
o Hunt, "Mechanisms and Disorders of Gastric Emptying," Annual Review of Medicine, 1983.
o Seigel, JA. "Biphasic Nature of Gastric Emptying" Gut 29: 35-39, 1988.
o Erdman, JW. "Bioavailability of Trace Minerals from Cereal and Legumes",
Cereal Chemistry 58(1), pages? 1981.
The general consensus is that an isotonic liquid might be likely to lead to elevated bioavailability since the transit through the stomach is rapid and might be expected to lead to improved nutrient stability due to minimal contact with stomach acid. Also, once the nutrients are in the small intestine, the nutrients that are absorbed via passive diffusion would be expected to be more bioavailable since they arrive at the major absorptive site at a high concentration. This elevated amount of nutrient on the lumen side sets up a concentration gradient which flows down the concentration gradient from high levels to lower levels inside the intestinal epithelial cells. However, for nutrients that are absorbed by specialised active transport processes, the establishment of a concentration gradient is not that important. The body will spend energy (as ATP) to transport those molecules across the cell membrane regardless of whether the nutrients are present in high or low concentrations.