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Advanced B


Scientific Studies Which Support Isotonix™ Advanced B-Complex:

    •    Benton D., et al.  Thiamine supplementation for mood and cognitive functioning.  Psychopharmacology. 129(1):66-71, 1997.
    •    Benton, D., et al.  The effects of nutrients on mood.  Public Health Nutr.  2(3A):403-409, 1999.
    •    Bhagavan, H. N., et al.  The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.  Pediatrics.  55(3):437-441, 1975.
    •    Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and
    •    Bryan, J., et al.  Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife.  J Nutr Health Aging.  8(4):226-232, 2004.
    •    Bryan, J., et al.  Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages.  Journal of Nutrition.  132(6):1345-1356, 2002.
    •    combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998.
    •    Coppen, A., et al.  Plasma folate and affective morbidity during long-term lithium therapy.  Br J Psychiatry.  141:87-89, 1982.
    •    Cummings, P. M., et al.  Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease.  J Am Coll Cardiol.  36:758-765, 2000.
    •    Dharmarajan, T. S., et al.  Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.  Geriatrics.  58(3):30-34, 2003.
    •    Doshi, S. N., et al.  Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.  Circulation.  105(1):22-26, 2002.
    •    Duthie, S. J., et al.  Homocysteine, B vitamin status, and cognitive function in the elderly.  American Journal of Clinical Nutrition.  75(5):908-913, 2002.
    •    Friso, S., et al.  Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk.  Am J Clin Nutr.  79(6):992-998, 2004.
    •    Grant, J. E., et al.  Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.  J Am Diet Assoc.  96(4):383-386, 1996.
    •    Hartvig, P., et al.  Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography.  Neural Trans.  102:91-97, 1995.
    •    Heap, L. C., et al.  Vitamin B status in patients with chronic fatigue syndrome.  J R Soc Med.  92(4):183-185, 1999.
    •    Heseker, H., et al.  Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency.  Ann N Y Acad Sci.  669:352-357, 1992.
    •    Jacobson, W., et al.  Serum folate and chronic fatigue syndrome.  Neurology.  43:2645-2647, 1993.
    •    Kelly, G. S.  Nutritional and botanical interventions to assist with the adaptation to stress.  Alternative Medicine Review.4 (4):249-265, 1999.
    •    Litoff, D., et al.  Effects of pantothenic acid supplementation on human exercise.  Med Sci Sport Exercise. 17(Supplement):287, 1985.
    •    Osada, K., et al.  Experimental study of fatigue provoked by biotin deficiency in mice.  Int J Vitam Nutr Res.  74(5):334-340, 2004.
    •    Quadri, P., et al.  Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia.  Am J Clin Nutr.  80(1):114-122, 2004.
    •    Riggs, K. M., et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.  American Journal of Clinical Nutrition.  63(3):306-314, 1996.
    •    Van den Berg M., et al.  Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.  Journal Vascular Surgery.  20(6):933-940, 1994.
    •    van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003.
    •    Vargiu, R., et al.  Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat.  Physiol Behav.  76(2):257-63, 2002.
    •    Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001.
    •    Werbach, M. R.  Nutritional strategies for treating chronic fatigue syndrome.  Alternative Medicine Review.  5(2):93-108, 2000.
    •    Woo, K. S., et al.  Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation.  American Journal of Medicine.  112(7):535-539, 2002.



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